Levinthal’s question answered … again?

Myeloablation for lymphoma--question answered?

The value of early myeloablative treatment of aggressive lymphoma in adults has been the subject of argument for many years. Before the addition of rituximab to the four-drug regimen known as CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone), a meta-analysis of randomized trials showed similar survival among patients undergoing up-front autologous stem-cell transplantation and t...

Will My Question Be Answered? Predicting "Question Answerability" in Community Question-Answering Sites

All askers who post questions in Community-based Question Answering (CQA) sites such as Yahoo! Answers, Quora or Baidu’s Zhidao, expect to receive an answer, and are frustrated when their questions remain unanswered. We propose to provide a type of “heads up” to askers by predicting how many answers, if at all, they will get. Giving a preemptive warning to the asker at posting time should reduc...

CADISS: a feasibility trial that answered its question

Anticoagulation after ischaemic stroke was a topic of major controversy for decades until a series of randomised clinical trials consistently showed no net benefi t of heparin or warfarin compared with aspirin. Any reduction in the risk of recurrent ischaemic stroke was off set by an increase in risk of intracerebral haemorrhages. One cause of stroke for which the eff ect of anticoagulation rem...

Typhoid fever & vaccine development: a partially answered question

Typhoid fever is a systemic disease caused by the human specific Gram-negative pathogen Salmonella enterica serovar Typhi (S. Typhi). The extra-intestinal infections caused by Salmonella are very fatal. The incidence of typhoid fever remains very high in impoverished areas and the emergence of multidrug resistance has made the situation worse. To combat and to reduce the morbidity and mortality...

Hormone replacement therapy for breast cancer survivors: an answered question?